Evaluation of distant results after lamivudine discontinuation in children with chronic hepatitis B

Folia Histochem Cytobiol. 2010 Jan;48(2):237-41. doi: 10.2478/v10042-08-0107-3.

Abstract

The aim of this study was to estimate distant results after discontinuation of long term lamivudine treatment in children with chronic hepatitis B. Furthermore, the emergence of HBV polymerase gene variants in YMDD motif during therapy was examined. Additionally, the most commonly occurring type of mutation in the polymerase YMDD region were investigated. The study involved 27 HBeAg positive children with chronic hepatitis B. Children included to lamivudine therapy were previously treated without effects with interferon alpha.

MeSH terms

  • Amino Acid Motifs / genetics
  • Child
  • Gene Products, pol / genetics
  • Genetic Variation
  • Hepatitis B, Chronic / drug therapy*
  • Humans
  • Lamivudine / therapeutic use*
  • Mutation
  • Reverse Transcriptase Inhibitors / therapeutic use*
  • Treatment Outcome

Substances

  • Gene Products, pol
  • P protein, Hepatitis B virus
  • Reverse Transcriptase Inhibitors
  • Lamivudine