doi: 10.1016/0027-5107(91)90154-g.
A note on efficient estimation of mutation rates using Luria-Delbrück fluctuation analysis
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- PMID: 2067540
- DOI: 10.1016/0027-5107(91)90154-g
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A note on efficient estimation of mutation rates using Luria-Delbrück fluctuation analysis
Mutat Res.
1991 Jul.
Abstract
The maximum likelihood and Luria-Delbrück P0 methods for the estimation of spontaneous mutation rates are compared. The maximum likelihood method is fully efficient, utilizing all available information in a fluctuation experiment, but can be numerically cumbersome. Under certain conditions, there is little loss of efficiency using the P0 method, which is readily implemented numerically. Design considerations should aid investigators in minimizing statistical errors associated with the statistical analysis of fluctuation experiments.
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