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Review
. 2010 Aug 1;9(15):2936-9.
doi: 10.4161/cc.9.15.12316. Epub 2010 Aug 7.

tRNA and Cytochrome C in Cell Death and Beyond

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Free PMC article
Review

tRNA and Cytochrome C in Cell Death and Beyond

Yide Mei et al. Cell Cycle. .
Free PMC article

Abstract

Both transfer RNA (tRNA) and cytochrome c are essential to cellular function: tRNA mediates protein synthesis while cytochrome c is required for oxidative phosphorylation and apoptosis induction. tRNA has recently been implicated as a direct regulator of the well-conserved apoptotic role of cytochrome c. Interaction between these molecules could potentially coordinate biosynthesis, energy production and apoptosis. Here we review the diversity and dynamics of tRNA and how this class of non-coding RNAs may regulate the role of cytochrome c in apoptosis. We comment on unanswered questions in the cell biology of this interaction and how answers may influence our understanding of disease.

Figures

Figure 1
Figure 1
Cytochrome c (red spheres) is present mostly in the mitochondrial inner membrane space of healthy cells, but translocates to the cytosol when intrinsic apoptotic stimuli are present. Transfer RNA (middle) may interact with cytochrome c and prevent association with Apaf-1, blocking formation of the apoptosome complex (upper right). When active, the apoptosome begins a proteolytic cascade that results in membrane blebbing, nuclear condensation and irreversible cell death.

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