Abstract
Although C-nitroso aromatic compounds have several bioactivities of medicinal interest, the biosynthetic enzymes involved in C-nitrosation have remained unknown until now. Here, we report the entire biosynthesis pathway of 4-hydroxy-3-nitrosobenzamide in Streptomyces murayamaensis, in which a tyrosinase-like copper-containing monooxygenase is responsible for the C-nitrosation. This finding indicates diverse catalytic functions of tyrosinase-like copper-containing monooxygenases in nature.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Benzamides / chemistry
-
Benzamides / metabolism*
-
Biocatalysis
-
Copper / metabolism*
-
Mixed Function Oxygenases / chemistry
-
Mixed Function Oxygenases / metabolism
-
Nitrates / metabolism*
-
Nitrosation
-
Nitroso Compounds / chemistry
-
Nitroso Compounds / metabolism*
-
Oxidoreductases / chemistry
-
Oxidoreductases / metabolism*
-
Streptomyces / chemistry
-
Streptomyces / enzymology
-
Streptomyces / metabolism*
Substances
-
Benzamides
-
Nitrates
-
Nitroso Compounds
-
Copper
-
3-nitrosobenzamide
-
Mixed Function Oxygenases
-
Oxidoreductases
-
copper oxidase
Associated data
-
PubChem-Substance/96107533
-
PubChem-Substance/96107534
-
PubChem-Substance/96107535
-
PubChem-Substance/96107536
-
PubChem-Substance/96107537
-
PubChem-Substance/96107538
-
PubChem-Substance/96107539
-
PubChem-Substance/96107540
-
PubChem-Substance/96107541
-
PubChem-Substance/96107542
-
PubChem-Substance/96107543
-
PubChem-Substance/96107544
-
PubChem-Substance/96107545
-
PubChem-Substance/96107546
-
PubChem-Substance/96107547