Regulation of fast-spiking basket cell synapses by the chloride channel ClC-2

Nat Neurosci. 2010 Sep;13(9):1047-9. doi: 10.1038/nn.2609. Epub 2010 Aug 1.

Abstract

Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Animals
  • Axons / physiology
  • Chloride Channels / metabolism*
  • Chlorides / metabolism
  • Cholecystokinin / metabolism
  • Hippocampus / physiology*
  • Homeostasis
  • In Vitro Techniques
  • Inhibitory Postsynaptic Potentials / physiology
  • Interneurons / physiology
  • Intracellular Space / metabolism
  • Membrane Potentials / physiology
  • Mice
  • Neurons / physiology*
  • Parvalbumins / metabolism
  • Pyramidal Cells / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, GABA-A / metabolism
  • Synapses / physiology*

Substances

  • Chloride Channels
  • Chlorides
  • ClC-2 chloride channels
  • Parvalbumins
  • Receptors, GABA-A
  • Cholecystokinin