International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers

J Magn Reson Imaging. 2010 Aug;32(2):315-9. doi: 10.1002/jmri.22245.


Purpose: To examine the reproducibility of the single breathhold T2* technique from different scanners, after installation of standard methodology in five international centers.

Materials and methods: Up to 10 patients from each center were scanned twice locally for local interstudy reproducibility of heart and liver T2*, and then flown to a central MR facility to be rescanned on a reference scanner for intercenter reproducibility. Interobserver reproducibility for all scans was also assessed.

Results: Of the 49 patients scanned, the intercenter reproducibility for T2* was 5.9% for the heart and 5.8% for the liver. Local interstudy reproducibility for T2* was 7.4% for the heart and 4.6% for the liver. Interobserver reproducibility for T2* was 5.4% for the heart and 4.4% for the liver.

Conclusion: These data indicate that T2* MR may be developed into a widespread test for tissue siderosis providing that well-defined and approved imaging and analysis techniques are used.

Trial registration: NCT00520559.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Iron / metabolism*
  • Iron Overload / pathology*
  • Liver / pathology*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Myocardium / pathology*
  • Observer Variation
  • Reference Values
  • Reproducibility of Results
  • Thalassemia / blood*


  • Iron

Associated data