Background and objective: The aim of this study is to evaluate diagnostic yield and the safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis ofbronchogenic carcinoma.
Methods: Between July, 2009 and February, 2010, 95 patients with mediastinal/hilar lymphadenopathy and/or intrathoracic peritracheal or peribronchial masses previously detected with CT scan underwent EBUS-TBNA. No rapid onsite cytology was performed.
Results: In all 95 patients, 60 cases were newly diagnosed lung cancer through the pathological examination and clinical follow-up certification. In 60 lung cancer cases, 112 samples were obtained from lymph nodes (LNs) and 11 samples were obtained from intrapulmonary lesions. Fifty-eight cases of patients were diagnosed, false negative in 2 cases. Sensitivity and specificity of EBUS-guided TBNA method in distinguishing benign from malignant LNs or thoracic masses were 96.67% and 100%, respectively. There was any major complication in this series, the procedure was uneventful.
Conclusion: EBUSTBNA seemed a safe and effective technique in making bronchogenic carcinoma diagnosis for mediastinal/hilar LNs and intra-pulmonary masses.
背景与目的: 本研究旨在评价超声支气管镜引导下的经支气管针吸活检（endobronchial ultrasoundguided transbronchial needle aspiration, EBUS-TBNA）对肺癌的诊断价值和安全性。
方法: 于2009年7月-2010年2月，对95例胸部CT检查显示纵隔/肺门淋巴结肿大和/或胸内气管或支气管旁肿块患者进行EBUS-TBNA，并未采取现场细胞学方法进行检测。
结果: 95例患者中，其中经病理学检查和临床随访验证新发肺癌患者60例。60例肺癌患者共穿刺112组淋巴结，肺内肿块11例。60例肺癌患者中通过EBUS-TBNA明确诊断58例，假阴性2例，敏感性为96.67%、特异性100%。EBUS-TBNA过程安全，全部病例无并发症发生。
结论: EBUS-TBNA是诊断肺癌安全、有效的方法。