Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors

IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Aug;57(8):1890-5. doi: 10.1109/TUFFC.2010.1630.


Previously, we reported new methods for ultrasound signal characterization using entropy, H(f); a generalized entropy, the Renyi entropy, I(f)(r); and a limiting form of Renyi entropy suitable for real-time calculation, I(f),(infinity). All of these quantities demonstrated significantly more sensitivity to subtle changes in scattering architecture than energy-based methods in certain settings. In this study, the real-time calculable limit of the Renyi entropy, I(f),(infinity), is applied for the imaging of angiogenic murine neovasculature in a breast cancer xenograft using a targeted contrast agent. It is shown that this approach may be used to reliably detect the accumulation of targeted nanoparticles at five minutes post-injection in this in vivo model.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms*
  • Animals
  • Breast Neoplasms / blood supply*
  • Breast Neoplasms / diagnostic imaging*
  • Contrast Media
  • Entropy
  • Female
  • Humans
  • Mice
  • Nanoparticles
  • Neovascularization, Pathologic / diagnostic imaging
  • Signal Processing, Computer-Assisted*
  • Transplantation, Heterologous
  • Ultrasonography / methods*


  • Contrast Media