The revitalized tau hypothesis on Alzheimer's disease

Arch Med Res. 2010 Apr;41(3):226-31. doi: 10.1016/j.arcmed.2010.03.007.


Many hypotheses have been raised regarding the pathophysiology of Alzheimer's disease (AD). Because amyloid beta peptide (Abeta) deposition in senile plaques appears as a late, nonspecific event, recent evidence points to tau phosphorylation and aggregation as the final common pathway in this multifactorial disease. Current approaches that provide evidence in favor of neuroimmunomodulation in AD and the roles of tau pathological modifications and aggregation into oligomers and filamentous forms are presented. We propose an integrative model on the pathogenesis of AD that includes several damage signals such as Abeta oligomers, oxygen free radicals, iron overload, homocysteine, cholesterol and LDL species. These activate microglia cells, releasing proinflammatory cytokines and producing neuronal degeneration and tau pathological modifications. Altered and aggregated forms of tau appear to act as a toxic stimuli contributing to neurodegeneration. Recent findings provide further support to the central role of tau in the pathogenesis of AD, so this protein has turned into a diagnostic and therapeutic target for this disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / etiology*
  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / therapy
  • Animals
  • Humans
  • Mice
  • Models, Neurological*
  • Neuroimmunomodulation
  • Protein Multimerization
  • Signal Transduction
  • tau Proteins / chemistry
  • tau Proteins / immunology
  • tau Proteins / physiology*


  • MAPT protein, human
  • tau Proteins