Dying alone: a tale of rho

Cell Stem Cell. 2010 Aug 6;7(2):135-6. doi: 10.1016/j.stem.2010.07.002.

Abstract

In this issue of Cell Stem Cell, Chen et al. (2010) and Ohgushi et al. (2010) report that Rho-mediated actomyosin contractility underlies the proclivity of human embryonic stem cells to undergo apoptosis upon dissociation or during low-density propagation, a property that challenges their in vitro isolation and manipulation.

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