Differential DNA damage response in stem and progenitor cells

Cell Stem Cell. 2010 Aug 6;7(2):145-7. doi: 10.1016/j.stem.2010.07.006.


The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells. In this issue of Cell Stem Cell, two groups address this hypothesis by examining DNA damage responses in hematopoietic stem and progenitor cells (Milyavsky et al., 2010; Mohrin et al., 2010).

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