Smoking-induced Change in Intrasynaptic Dopamine Concentration: Effect of Treatment for Tobacco Dependence

Psychiatry Res. 2010 Sep 30;183(3):218-24. doi: 10.1016/j.pscychresns.2009.06.004. Epub 2010 Aug 3.

Abstract

The aim of this study was to determine whether standard treatments for Tobacco Dependence affect smoking-induced changes in intrasynaptic dopamine (DA) concentration. Forty-three otherwise healthy adult cigarette smokers (10 to 40 cigarettes per day) were treated with either practical group counseling (PGC) psychotherapy (n=14), bupropion HCl (n=14), or matching pill placebo (n=15) (random assignment) for 8 weeks. Before and after treatment, each subject underwent a bolus-plus-continuous-infusion (11)C-raclopride positron emission tomography (PET) scanning session, during which he or she smoked a regular cigarette. The PET scanning outcome measure of interest was percent change in smoking-induced (11)C-raclopride binding potential (BP(ND)) in the ventral caudate/nucleus accumbens (VCD/NAc), as an indirect measure of DA release. Although the entire study sample had a smaller mean smoking-induced reduction in VCD/NAc BP(ND) after treatment (compared to before treatment), this change was highly correlated with smaller total cigarette puff volumes (and not other treatment variables). These data indicate that smoking-induced DA release is dose-dependent, and is not significantly affected by reductions in daily smoking levels or treatment type.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Bupropion / therapeutic use*
  • Dopamine / metabolism*
  • Dopamine Antagonists / pharmacokinetics
  • Dopamine Uptake Inhibitors / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Positron-Emission Tomography / methods
  • Raclopride / pharmacokinetics
  • Smoking / metabolism*
  • Smoking / psychology
  • Statistics as Topic
  • Synapses / diagnostic imaging
  • Synapses / metabolism*
  • Tobacco Use Disorder / diagnostic imaging
  • Tobacco Use Disorder / drug therapy*
  • Young Adult

Substances

  • Dopamine Antagonists
  • Dopamine Uptake Inhibitors
  • Bupropion
  • Raclopride
  • Dopamine