Effect of Astaxanthin Supplementation on Inflammation and Cardiac Function in BALB/c Mice

Anticancer Res. 2010 Jul;30(7):2721-5.

Abstract

Astaxanthin is an antioxidant with immunomodulatory, anti-inflammatory and anticancer properties. This study evaluated the use of dietary astaxanthin to decrease oxidative stress and improve cardiac function, thereby providing a potential cardioprotective supplement. Female BALB/c mice (8 weeks of age) were fed a semi-synthetic diet containing 0, 0.02 or 0.08% astaxanthin for 8 weeks. Cardiac function was assessed by echocardiography bi-weekly, and blood and tissue samples were collected at 8 weeks. Plasma astaxanthin concentrations increased (p<0.05) dose-dependently to 0.5 and 4 mumol/l in the astaxanthin-supplemented mice. Blood glutathione concentrations and lymphocyte mitochondrial membrane potential were not significantly affected by astaxanthin treatment. However, mice fed 0.08% astaxanthin had higher (p<0.05) heart mitochondrial membrane potential and contractility index compared to the control group. These results support the possible use of dietary astaxanthin for cardiac protection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Antioxidants / pharmacology*
  • Cardiotonic Agents / pharmacology*
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Echocardiography
  • Female
  • Glutathione / blood
  • Glutathione Disulfide / blood
  • Heart / drug effects*
  • Lymphocytes / drug effects
  • Membrane Potential, Mitochondrial / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Mitochondria, Heart / drug effects
  • Myocardium / metabolism
  • Oxidative Stress / drug effects
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / biosynthesis
  • Xanthophylls / blood
  • Xanthophylls / pharmacokinetics
  • Xanthophylls / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Antioxidants
  • Cardiotonic Agents
  • Tumor Necrosis Factor-alpha
  • Xanthophylls
  • astaxanthine
  • Glutathione
  • Glutathione Disulfide