Modeling the endoplasmic reticulum unfolded protein response

Nat Struct Mol Biol. 2010 Aug;17(8):924-5. doi: 10.1038/nsmb0810-924.

Abstract

A detailed quantitative model of signaling by IRE1 sheds light on the mechanism of its activation by endoplasmic reticulum stress and addresses a long-standing controversy in the field.

Publication types

  • News

MeSH terms

  • Endoplasmic Reticulum / metabolism*
  • Endoplasmic Reticulum Chaperone BiP
  • Heat-Shock Proteins / metabolism
  • Membrane Glycoproteins / metabolism
  • Models, Biological*
  • Protein Serine-Threonine Kinases / metabolism
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction
  • Stress, Physiological
  • Unfolded Protein Response*

Substances

  • Endoplasmic Reticulum Chaperone BiP
  • Heat-Shock Proteins
  • Membrane Glycoproteins
  • Saccharomyces cerevisiae Proteins
  • IRE1 protein, S cerevisiae
  • Protein Serine-Threonine Kinases