Abstract
A detailed quantitative model of signaling by IRE1 sheds light on the mechanism of its activation by endoplasmic reticulum stress and addresses a long-standing controversy in the field.
MeSH terms
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Endoplasmic Reticulum / metabolism*
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Endoplasmic Reticulum Chaperone BiP
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Heat-Shock Proteins / metabolism
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Membrane Glycoproteins / metabolism
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Models, Biological*
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Protein Serine-Threonine Kinases / metabolism
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / metabolism
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Signal Transduction
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Stress, Physiological
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Unfolded Protein Response*
Substances
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Endoplasmic Reticulum Chaperone BiP
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Heat-Shock Proteins
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Membrane Glycoproteins
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Saccharomyces cerevisiae Proteins
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IRE1 protein, S cerevisiae
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Protein Serine-Threonine Kinases