Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Aug;9(8):921-7.

Statins in Skin: Research and Rediscovery, From Psoriasis to Sclerosis

Affiliations
  • PMID: 20684142
Review

Statins in Skin: Research and Rediscovery, From Psoriasis to Sclerosis

Adaeze Egesi et al. J Drugs Dermatol. .

Abstract

Statins, initially developed as antimicrobials, are primarily considered cholesterol-lowering agents. Recently, researchers discovered anti-inflammatory properties of statins. Studies on the effects of statins and the alterations noted include: bench work that supported a Th1/Th2 skew to Th1, altered lymphocyte migration, inhibition of MHC-II induction and cytokine release on antigen-presenting cells, inhibition of mast cell degranulation and inhibition of Th17 cells and IL-17 production. In addition to the anti-inflammatory properties, statins have been found to induce apoptosis in melanoma models. The potential therapeutic value of statins is illustrated in the management of alopecia areata, atopic dermatitis, psoriasis, systemic lupus erythematosus, cutaneous T-cell lymphomas, cutaneous melanoma, mastocytosis and more. This manuscript presents a comprehensive review of statins and their potential dermatologic application.

Similar articles

See all similar articles

Cited by 4 articles

MeSH terms

Substances

Feedback