Subacute penile numbness after brachytherapy for prostate cancer

Brachytherapy. 2011 Jan-Feb;10(1):64-7. doi: 10.1016/j.brachy.2010.02.197. Epub 2010 Aug 4.

Abstract

Purpose: Penile numbness is a rare complication of permanent prostate brachytherapy, and optimal clinical management remains unclear. We present such a case and discuss pathophysiology and clinical management strategies.

Methods and materials: A 68-year-old male presented with a serum prostate-specific antigen level of 6.9 ng/mL, Gleason score of 7 (3+4), and clinical T1c adenocarcinoma of the prostate. After a permanent prostate brachytherapy implant with (125)I monotherapy to a dose of 145Gy, the patient developed complete penile numbness postoperatively on the third day.

Results: The patient experienced complete restoration of penile sensation and function by postoperative day 9 with conservative management.

Conclusions: Subacute penile shaft numbness after brachytherapy is rare and is caused by dorsal penile nerve compression. Over the course of a week, the restoration of penile sensation is likely to occur with conservative management.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / radiotherapy*
  • Aged
  • Brachytherapy / adverse effects
  • Humans
  • Hypesthesia / etiology*
  • Hypesthesia / physiopathology
  • Male
  • Penis / physiopathology
  • Penis / radiation effects*
  • Prostate-Specific Antigen / blood
  • Prostatic Neoplasms / radiotherapy*
  • Radiation Injuries / etiology*
  • Radiation Injuries / physiopathology

Substances

  • Prostate-Specific Antigen