Protective effect of beta-casomorphin-7 on type 1 diabetes rats induced with streptozotocin

Peptides. 2010 Sep;31(9):1725-9. doi: 10.1016/j.peptides.2010.05.016. Epub 2010 Jun 1.


The present study was aimed to investigate the possible effects of beta-casomorphin-7, against hyperglycemia and free radical-mediated oxidative stress in streptozotocin-induced diabetic rats by assaying the blood glucose level and the activity of plasma enzymatic antioxidants, such as superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-Px). A significant increase in the levels of both blood glucose and oxidative stress with a predominant decrease in antioxidant status was observed in the diabetic rats when compared to control rats. After 15 days oral administration of beta-casomorphin-7 (7.5 x 10(-8) mol/day), the elevated blood glucose level was reduced. Oral administration of beta-CM-7 to diabetic rats showed an increase in the level of plasma insulin, the elevated plasma glucagon level was markedly reduced by the oral administration of beta-CM-7. Oral administration of beta-CM-7 to the diabetic group of rats also showed a significant elevation in the activity of SOD and catalase. Thus, the results of the present study suggest that beta-casomorphin-7 can protect rats from hyperglycemia and free radical-mediated oxidative stress in diabetic rats.

MeSH terms

  • Animals
  • Antioxidants / therapeutic use*
  • Blood Glucose / analysis
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetes Mellitus, Type 1 / metabolism
  • Endorphins / therapeutic use*
  • Glucagon / blood
  • Glycogen / metabolism
  • Hyperglycemia / prevention & control
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / blood
  • Male
  • Malondialdehyde / blood
  • Oxidative Stress / drug effects
  • Oxidoreductases / blood
  • Peptide Fragments / therapeutic use*
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Streptozocin
  • Time Factors
  • Weight Gain / drug effects


  • Antioxidants
  • Blood Glucose
  • Endorphins
  • Hypoglycemic Agents
  • Insulin
  • Peptide Fragments
  • Malondialdehyde
  • Streptozocin
  • beta-casomorphin 7
  • Glycogen
  • Glucagon
  • Oxidoreductases