A collaborative study of cancer incidence and mortality among vinyl chloride workers

Scand J Work Environ Health. 1991 Jun;17(3):159-69. doi: 10.5271/sjweh.1715.


A large European multicentric cohort study has been coordinated by the International Agency for Research on Cancer with the objectives of investigating the dose-response relationship between liver cancer and exposure to vinyl chloride and assessing cancer risk for sites other than the liver. A nearly threefold increase in liver cancer was detected on the basis of 24 observed deaths and 8.4 expected (standardized mortality ratio 286, 95% confidence interval 186-425). The excess from liver cancer was clearly related to time since first exposure, duration of employment, and estimated ranked and quantitative exposures. Other cancer sites investigated on the basis of a priori hypotheses were either not in excess (lung) or apparently unrelated to the exposure variables (brain and lymphoma).

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Neoplasms / chemically induced
  • Brain Neoplasms / epidemiology
  • Cause of Death
  • Cohort Studies
  • Hemangiosarcoma / chemically induced*
  • Hemangiosarcoma / epidemiology
  • Hemangiosarcoma / mortality
  • Humans
  • Liver Neoplasms / chemically induced*
  • Liver Neoplasms / epidemiology
  • Liver Neoplasms / mortality
  • Lymphoma / chemically induced
  • Lymphoma / epidemiology
  • Middle Aged
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / epidemiology
  • Regression Analysis
  • Risk Factors
  • Vinyl Chloride / adverse effects*


  • Vinyl Chloride