Mortality of employees in plants manufacturing 4,4'-bipyridyl

Scand J Work Environ Health. 1991 Jun;17(3):175-8. doi: 10.5271/sjweh.1714.


A historical-prospective cohort study was conducted of 729 male employees of plants manufacturing 4,4'-bipyridyl. The cohort was studied because employment in some of the plants had been linked to malignant and nonmalignant skin lesions attributed to exposure to tarry by-products. The overall mortality experience of the cohort did not show any statistically significant findings. More-detailed analysis of subdivision of the cohort gave results that justified further inquiry into lung cancer incidence. A nested case-referent study did not indicate that any occupational factor other than employment in a bipyridyl plant was related to the incidence of lung cancer. The epidemiologic, toxicologic, and industrial hygiene information was assessed, and it was concluded that there was no evidence of a plausible occupational hazard of lung cancer to the bipyridyl workers, but that a follow-up of the cohort after an interval of five years should be undertaken.

MeSH terms

  • Cohort Studies
  • Ethylene Glycols / adverse effects*
  • Humans
  • Lung Neoplasms / chemically induced
  • Lung Neoplasms / mortality
  • Male
  • Methyl Ethers / adverse effects*
  • Mortality*
  • Occupational Exposure
  • Prospective Studies
  • Pyridines / adverse effects*
  • Risk Factors
  • Skin Diseases / chemically induced
  • Skin Diseases / mortality
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / mortality


  • Ethylene Glycols
  • Methyl Ethers
  • Pyridines
  • diglyme
  • pyridine
  • 4,4'-bipyridyl