Asymmetrical contribution of brain structures to treatment-resistant depression as illustrated by effects of right subgenual cingulum stimulation

J Neuropsychiatry Clin Neurosci. Summer 2010;22(3):265-77. doi: 10.1176/jnp.2010.22.3.265.


Major depressive disorder is one of the most common psychiatric disorders, with a worldwide lifetime prevalence rate of 10%-20% in women and a slightly lower rate in men. While many patients are successfully treated using established therapeutic strategies, a significant percentage of patients fail to respond. This report describes the successful recovery of a previously treatment-resistant patient following right unilateral deep brain stimulation of Brodmann's area 25. Current therapeutic approaches to treatment-resistant patients are reviewed in the context of this case with an emphasis on the role of the right and left hemispheres in mediating disease pathogenesis and clinical recovery.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / physiopathology*
  • Deep Brain Stimulation / methods*
  • Depressive Disorder, Major / etiology
  • Depressive Disorder, Major / physiopathology*
  • Depressive Disorder, Major / therapy*
  • Functional Laterality
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome