Clinical manifestations and treatment of Churg-Strauss syndrome

Rheum Dis Clin North Am. 2010 Aug;36(3):527-43. doi: 10.1016/j.rdc.2010.05.003. Epub 2010 Jun 20.


Churg-Strauss syndrome (CSS) is a systemic necrotizing vasculitis affecting small to medium-sized vessels, and characterized by asthma, blood hypereosinophilia, and eosinophil-rich granulomatous inflammation of the respiratory tract. In the past few years the pathogenesis of the disease and its clinical manifestations have been clarified, fostering important advances in the treatment of CSS. Systemic corticosteroids are still considered the cornerstone of treatment. Many issues need to be addressed, such as how to maintain remission, prevent disease relapses, and treat refractory disease. This review provides a clinical overview of CSS and a summary of the current treatments and novel therapies.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Antibodies, Antineutrophil Cytoplasmic / immunology*
  • Antibodies, Monoclonal / therapeutic use
  • Asthma / complications
  • Asthma / immunology
  • Churg-Strauss Syndrome / complications
  • Churg-Strauss Syndrome / drug therapy
  • Churg-Strauss Syndrome / immunology*
  • Drug Therapy, Combination
  • Eosinophilia / complications
  • Eosinophilia / drug therapy
  • Eosinophilia / immunology
  • Humans
  • Immunologic Factors / therapeutic use
  • Immunosuppressive Agents / administration & dosage
  • Remission Induction


  • Adrenal Cortex Hormones
  • Antibodies, Antineutrophil Cytoplasmic
  • Antibodies, Monoclonal
  • Immunologic Factors
  • Immunosuppressive Agents