P66SHC and ageing: ROS and TOR?

Aging (Albany NY). 2010 Aug;2(8):514-8. doi: 10.18632/aging.100182.

Abstract

Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging* / pathology
  • Aging* / physiology
  • Animals
  • Caloric Restriction
  • DNA Damage
  • Disease Models, Animal
  • Food
  • Glucose Metabolism Disorders / genetics
  • Glucose Metabolism Disorders / metabolism
  • Insulin Resistance / physiology
  • Mice
  • Mitochondria / physiology
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Oxidative Stress / physiology
  • Proteostasis Deficiencies / genetics
  • Proteostasis Deficiencies / metabolism
  • Reactive Oxygen Species / metabolism*
  • Ribosomal Protein S6 Kinases / physiology*
  • Shc Signaling Adaptor Proteins / physiology*
  • Src Homology 2 Domain-Containing, Transforming Protein 1
  • TOR Serine-Threonine Kinases / physiology*

Substances

  • Reactive Oxygen Species
  • Shc Signaling Adaptor Proteins
  • Shc1 protein, mouse
  • Src Homology 2 Domain-Containing, Transforming Protein 1
  • Ribosomal Protein S6 Kinases
  • TOR Serine-Threonine Kinases