Abstract
Both Reactive Oxygen Species (ROS) and hyperactivation of the nutrient-sensing mTOR/S6 kinase cascade have been linked to aging and age-related diseases as well as to the anti-aging effect of calorie restriction. Recent findings that the pro-aging and pro-oxidant molecule p66shc contributes to S6K activation by nutrients and promotes insulin resistance and diabetes in mice may provide an answer to the "ROS or TOR?" dilemma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aging* / pathology
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Aging* / physiology
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Animals
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Caloric Restriction
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DNA Damage
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Disease Models, Animal
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Food
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Glucose Metabolism Disorders / genetics
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Glucose Metabolism Disorders / metabolism
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Insulin Resistance / physiology
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Mice
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Mitochondria / physiology
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Neoplasms / genetics
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Neoplasms / metabolism
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Oxidative Stress / physiology
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Proteostasis Deficiencies / genetics
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Proteostasis Deficiencies / metabolism
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Reactive Oxygen Species / metabolism*
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Ribosomal Protein S6 Kinases / physiology*
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Shc Signaling Adaptor Proteins / physiology*
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Src Homology 2 Domain-Containing, Transforming Protein 1
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TOR Serine-Threonine Kinases / physiology*
Substances
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Reactive Oxygen Species
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Shc Signaling Adaptor Proteins
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Shc1 protein, mouse
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Ribosomal Protein S6 Kinases
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TOR Serine-Threonine Kinases