Bronchial blood supply after lung transplantation without bronchial artery revascularization

Curr Opin Organ Transplant. 2010 Oct;15(5):563-7. doi: 10.1097/MOT.0b013e32833deca9.

Abstract

Purpose of review: This review discusses how the bronchial artery circulation is interrupted following lung transplantation and what may be the long-term complications of compromising systemic blood flow to allograft airways.

Recent findings: Preclinical and clinical studies have shown that the loss of airway microcirculations is highly associated with the development of airway hypoxia and an increased susceptibility to chronic rejection.

Summary: The bronchial artery circulation has been highly conserved through evolution. Current evidence suggests that the failure to routinely perform bronchial artery revascularization at the time of lung transplantation may predispose patients to develop the bronchiolitis obliterans syndrome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Anastomosis, Surgical
  • Animals
  • Bronchial Arteries / physiopathology
  • Bronchial Arteries / surgery*
  • Bronchiolitis Obliterans / etiology
  • Bronchiolitis Obliterans / physiopathology
  • Graft Rejection / etiology
  • Graft Rejection / physiopathology
  • Graft Survival
  • Humans
  • Lung / blood supply*
  • Lung / surgery*
  • Lung Transplantation* / adverse effects
  • Pulmonary Circulation*
  • Regional Blood Flow
  • Reperfusion Injury / etiology
  • Reperfusion Injury / physiopathology
  • Transplantation, Homologous
  • Treatment Outcome