Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?

S Oreland; L Daoura; L Gustafsson-Ericson; M Damberg; P Hyytiä; L Oreland; Ingrid Nylander

doi:10.1007/s00702-010-0448-x

Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol consumption?

J Neural Transm (Vienna). 2010 Sep;117(9):1077-81. doi: 10.1007/s00702-010-0448-x. Epub 2010 Aug 6.

Authors

S Oreland¹, L Daoura, L Gustafsson-Ericson, M Damberg, P Hyytiä, L Oreland, Ingrid Nylander

Affiliation

¹ Division of Pharmacology, Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 Uppsala, Sweden.

Abstract

Genes involved in alcoholism have consensus sites for the transcription factor activator protein (TFAP) 2beta. In the present study, we investigated TFAP-2beta protein levels in the ethanol-preferring alko, alcohol (AA) and the ethanol-avoiding alko, non-alcohol (ANA) rat lines. Furthermore, basal and ethanol-induced TFAP-2beta levels were examined in Wistar rats exposed to different early postnatal environments that are known to affect later ethanol consumption. Taken together, we found differences in brainstem TFAP-2beta protein between the AA and ANA rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohol Drinking / genetics
Alcohol Drinking / metabolism*
Analysis of Variance
Animals
Brain Stem / metabolism*
Ethanol / pharmacology*
Maternal Deprivation*
Rats
Rats, Wistar
Social Environment*
Transcription Factor AP-2 / genetics
Transcription Factor AP-2 / metabolism*

Substances

Transcription Factor AP-2
Ethanol