Zinc and biotin deficiencies after pancreaticoduodenectomy

Acta Gastroenterol Belg. Apr-Jun 2010;73(2):283-6.


We report zinc and biotin deficiencies after pancreaticoduodenectomy in a 16 year old female presenting clinically with marked alopecia, total body hair loss, dry skin with scales, and maculopathy with significant vision loss. These micronutrient deficiencies likely occurred due to resection of the duodenum and proximal jejunum, sites of primary absorption of several micronutrients and their protein carriers, including zinc and biotin. Early diagnosis is essential to prevent irreversible sequelae. Adequate supplementation of zinc and biotin as well as dietary advice is needed for clinical improvement.

Publication types

  • Case Reports

MeSH terms

  • Acrodermatitis / etiology*
  • Adolescent
  • Biotin / deficiency*
  • Fatty Liver / etiology
  • Female
  • Humans
  • Malabsorption Syndromes / etiology
  • Pancreatic Neoplasms / surgery
  • Pancreaticoduodenectomy / adverse effects*
  • Zinc / deficiency


  • Biotin
  • Zinc