Role of tissue factor in venous thrombosis

Annu Rev Physiol. 2011;73:515-25. doi: 10.1146/annurev-physiol-042210-121137.


Venous thromboembolism (VTE) is a leading cause of morbidity and mortality worldwide. However, the mechanisms by which clots are formed in the deep veins have not been determined. Tissue factor (TF) is the primary initiator of the coagulation cascade and is essential for hemostasis. Under pathological conditions, TF is released into the circulation on small-membrane vesicles termed microparticles (MPs). Recent studies suggest that elevated levels of MP TF may trigger thrombosis. This review provides an overview of the role of TF in VTE.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers / blood
  • Blood Coagulation / physiology
  • Cell-Derived Microparticles / physiology
  • Disease Models, Animal
  • Humans
  • Mice
  • Neoplasms / physiopathology
  • Thromboplastin / biosynthesis
  • Thromboplastin / physiology*
  • Venous Thrombosis / physiopathology*
  • Venous Thrombosis / surgery
  • Wounds and Injuries / physiopathology


  • Biomarkers
  • Thromboplastin