Reproductive life disorders in Italian celiac women. A case-control study

BMC Gastroenterol. 2010 Aug 6;10:89. doi: 10.1186/1471-230X-10-89.

Abstract

Background: The aim of this study is to explore the association between celiac disease and menstrual cycle, gestation and puerperal disorders.

Methods: The association between celiac disease and menstrual cycle, gestation and puerperal disorders in a sample of 62 childbearing age women (15-49 age) was assessed within an age and town of residence matched case-control study conducted in 2008. Main outcome measures were the presence of one or more disorders in menstrual cycle and the presence of one or more complication during pregnancy.

Results: 62 celiac women (median age: 31.5, range: 17-49) and 186 healthy control (median age: 32.5, range: 15-49) were interviewed. A higher percentage of menstrual cycle disorders has been observed in celiac women. 19.4% frequency of amenorrhea was reported among celiac women versus 2.2% among healthy controls (OR = 33, 95% CI = 7.17-151.8;, p = 0.000). An association has been observed between celiac disease and oligomenorrhea, hypomenorrhea, dysmenorrhea and metrorrhagia (p < 0.05). The likelihood of having at least one complication during pregnancy has been estimated to be at least four times higher in celiac women than in healthy women (OR = 4.1, 95% CI = 2-8.6, p = 0.000). A significant correlation has emerged for celiac disease and threatened abortion, gestational hypertension, placenta abruption, severe anaemia, uterine hyperkinesia, intrauterine growth restriction (p < 0.001). A shorter gestation has on average been observed in celiac women together with a lower birth weight of celiac women babies (p < 0.001).

Conclusions: The occurrence of a significant correlation between celiac disease and reproductive disorders could suggest to consider celiac disease diagnostic procedures (serological screening) in women affected by these disorders.

MeSH terms

  • Adolescent
  • Adult
  • Amenorrhea / epidemiology
  • Amenorrhea / physiopathology
  • Case-Control Studies
  • Celiac Disease / epidemiology*
  • Celiac Disease / ethnology*
  • Celiac Disease / physiopathology
  • Comorbidity
  • Female
  • Fetal Growth Retardation / epidemiology
  • Fetal Growth Retardation / physiopathology
  • Humans
  • Hypertension, Pregnancy-Induced / epidemiology
  • Hypertension, Pregnancy-Induced / physiopathology
  • Italy
  • Menstruation Disturbances / epidemiology*
  • Menstruation Disturbances / physiopathology
  • Middle Aged
  • Oligomenorrhea / epidemiology
  • Oligomenorrhea / physiopathology
  • Pregnancy
  • Pregnancy Complications / epidemiology*
  • Pregnancy Complications / physiopathology
  • Prevalence
  • Young Adult