Association to the Glypican-5 gene in multiple sclerosis

J Neuroimmunol. 2010 Sep 14;226(1-2):194-7. doi: 10.1016/j.jneuroim.2010.07.003. Epub 2010 Aug 6.


Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Child
  • Chromosomes, Human, Pair 13 / genetics
  • Female
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study / methods
  • Glypicans / genetics*
  • Humans
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Multiple Sclerosis / genetics*
  • Norway
  • Polymorphism, Single Nucleotide / genetics*
  • Young Adult


  • Glypicans