Pulmonary manifestations of the idiopathic inflammatory myopathies

Clin Chest Med. 2010 Sep;31(3):501-12. doi: 10.1016/j.ccm.2010.05.008.


Pulmonary involvement in myositis includes interstitial lung disease (ILD), respiratory muscle weakness, aspiration, infections, and drug-induced disease. ILD may precede myositis, and results in increased morbidity and mortality rates. Initial evaluation should include pulmonary function tests and high-resolution computed tomography. Nonspecific interstitial pneumonia (NSIP) is the most common histologic pattern on lung biopsy. Treatment usually consists of a combination of steroids and other immunosuppressive agents, and the response depends on the clinical presentation and underlying histology.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / complications*
  • Autoimmune Diseases / immunology
  • Biomarkers / blood
  • Dermatomyositis / complications*
  • Dermatomyositis / immunology
  • Dyspnea / etiology*
  • Humans
  • Lung Diseases, Interstitial / complications
  • Lung Diseases, Interstitial / diagnosis*
  • Lung Diseases, Interstitial / etiology*
  • Lung Diseases, Interstitial / therapy
  • Pleural Diseases / complications
  • Pleural Diseases / etiology
  • Polymyositis / complications*
  • Polymyositis / immunology
  • Prognosis


  • Biomarkers