Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia

Am J Obstet Gynecol. 2010 Oct;203(4):366.e1-6. doi: 10.1016/j.ajog.2010.06.036. Epub 2010 Aug 8.


Objective: Vitamin D deficiency has been linked to adverse pregnancy outcomes. The purpose of this investigation was to assess total 25-hydroxyvitamin D (25-OH-D) levels at diagnosis of early-onset severe preeclampsia (EOSPE).

Study design: After institutional review board approval, we enrolled subjects with EOSPE (<34 weeks' gestation with severe preeclampsia) in this case-control investigation in a 1:2 ratio with gestation-matched, contemporaneous control subjects. Demographic and outcome information was collected for each subject. Plasma total 25-OH-D levels were determined by radioimmunoassay and reported in nanograms per milliliter. Results were analyzed by Mann-Whitney U and multivariable regression.

Results: Subjects with EOSPE (n = 50) were noted to have decreased total 25-OH-D levels relative to healthy control subjects (n = 100; P < .001). This difference in total 25-OH-D remained significant after control for potential confounders.

Conclusion: Total 25-OH-D is decreased at diagnosis of EOSPE. Further study is needed to understand the impact of vitamin D deficiency on pregnancy outcomes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Black People
  • Case-Control Studies
  • Female
  • Humans
  • Pre-Eclampsia / blood*
  • Pregnancy
  • Radioimmunoassay
  • Severity of Illness Index
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / diagnosis
  • White People


  • Vitamin D
  • 25-hydroxyvitamin D