Kidney function, albuminuria, and all-cause mortality in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study

Am J Kidney Dis. 2010 Nov;56(5):861-71. doi: 10.1053/j.ajkd.2010.05.017. Epub 2010 Aug 8.


Background: Chronic kidney disease and albuminuria are associated with increased risk of all-cause mortality.

Study design: Prospective observational cohort study.

Setting & participants: 17,393 participants (mean age, 64.3 ± 9.6 years) in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study.

Predictor: Estimated glomerular filtration rate (eGFR), urinary albumin-creatinine ratio (ACR).

Outcome: All-cause mortality (710 deaths); median duration of follow-up, 3.6 years. MEASUREMENTS & ANALYSIS: Categories of eGFR (90 to <120, 60 to <90, 45 to <60, 30 to <45, and 15 to <30 mL/min/1.73 m(2)) and urinary ACR (<10 mg/g or normal, 10 to <30 mg/g or high normal, 30 to 300 mg/g or high, and >300 mg/g or very high). Cox proportional hazards models were adjusted for demographic factors, cardiovascular covariates, and hemoglobin level.

Results: The background all-cause mortality rate for participants with normal ACR, eGFR of 90 to <120 mL/min/1.73 m(2), and no coronary heart disease was 4.3 deaths/1,000 person-years. Higher ACR was associated with an increased multivariable-adjusted HR for all-cause mortality within each eGFR category. Decreased eGFR was associated with a higher adjusted HR for all-cause mortality for participants with high-normal (P = 0.01) and high (P < 0.001) ACRs, but not those with normal or very high ACRs.

Limitations: Only 1 laboratory assessment for serum creatinine and ACR was available.

Conclusions: Increased albuminuria was an independent risk factor for all-cause mortality. Decreased eGFR was associated with increased mortality risk in those with high-normal and high ACRs. The mortality rate was low in the normal-ACR group and increased in the very-high-ACR group, but did not vary with eGFR in these groups.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Albuminuria / metabolism
  • Albuminuria / mortality
  • Albuminuria / physiopathology*
  • Cause of Death / trends
  • Creatinine / urine
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate / physiology*
  • Humans
  • Kidney / physiopathology*
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Survival Rate / trends
  • Time Factors
  • United States / epidemiology


  • Creatinine