Relationships between structures of hydroxyflavones and their antioxidative effects

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5510-3. doi: 10.1016/j.bmcl.2010.07.068. Epub 2010 Jul 21.


Even hydroxyflavones show diverse biological functions, they have two common features such as showing antioxidative effects and containing hydroxyl groups. The authors tested the antioxidative effects of thirty hydroxyflavones using 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. While the scavenging activity of galangin, 3,5,7-trihydroxyflavone was 52.5%, fisetin, 3,7,3',4'-tetrahydroxyflavone showed 85.2%. To investigate the relationships between the structures of hydroxyflavones and their antioxidative effects, the three-dimensional quantitative structure-activity relationships were examined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry*
  • Antioxidants / pharmacology*
  • Flavones / chemistry*
  • Flavones / pharmacology*
  • Flavonoids / chemistry
  • Flavonoids / pharmacology
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology
  • Models, Molecular
  • Quantitative Structure-Activity Relationship


  • Antioxidants
  • Flavones
  • Flavonoids
  • Free Radical Scavengers
  • galangin
  • fisetin