Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5552-8. doi: 10.1016/j.bmcl.2010.07.043. Epub 2010 Jul 15.


We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Databases, Factual
  • Drug Design*
  • Ligands
  • Models, Molecular
  • Molecular Structure
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Structure-Activity Relationship
  • Xenopus


  • Ligands
  • NR2B NMDA receptor
  • Receptors, N-Methyl-D-Aspartate