Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010;21(3):763-7.
doi: 10.3233/JAD-2010-100597.

An Association Study of 21 Potential Alzheimer's Disease Risk Genes in a Finnish Population

Affiliations

An Association Study of 21 Potential Alzheimer's Disease Risk Genes in a Finnish Population

Timo Sarajärvi et al. J Alzheimers Dis. .

Abstract

Alzheimer's disease (AD) is a genetically complex disorder encompassing several individual susceptibility genes with low risk effects. To assess the risk gene effects in a cohort consisting of ∼ 1300 Finnish AD patients and controls, 21 candidate gene polymorphisms were selected for genotyping on the basis of the meta-analyses retrieved from the AlzGene database. A significant genotype and allele association with AD was observed with rs1800629 in the tumor necrosis factor α (TNF). Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

Substances

LinkOut - more resources

Feedback