Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Nat Genet. 2010 Sep;42(9):739-741. doi: 10.1038/ng.639. Epub 2010 Aug 8.


We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Chromosomes, Human, Pair 18* / genetics
  • Gambia
  • Genetic Loci*
  • Genetic Predisposition to Disease*
  • Genetics, Population
  • Genome-Wide Association Study
  • Ghana
  • Humans
  • Linkage Disequilibrium
  • Odds Ratio
  • Polymorphism, Single Nucleotide
  • Tuberculosis / genetics*