The vessel wall: A forgotten player in post thrombotic syndrome

Thromb Haemost. 2010 Oct;104(4):681-92. doi: 10.1160/TH10-03-0183. Epub 2010 Aug 5.


Much research in venous thrombotic diseases focuses on the acute thrombotic process such as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic syndrome, and this can cause significant patient disability. Little research has focused on the vein wall injury response to the thrombotic inflammatory insult. Herein, we review what is currently known about this process with emphasis on the matrix, mediators, and vascular medial smooth muscle response after thrombotic injury. Translational therapies and potential future agents are reviewed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anticoagulants / therapeutic use*
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Drug Therapy / trends
  • Humans
  • Inflammation
  • Intercellular Signaling Peptides and Proteins / immunology
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Matrix Metalloproteinases / immunology
  • Matrix Metalloproteinases / metabolism
  • Myocytes, Smooth Muscle / drug effects*
  • Myocytes, Smooth Muscle / metabolism
  • Myocytes, Smooth Muscle / pathology
  • Syndrome
  • Veins / pathology
  • Venous Thrombosis / drug therapy*
  • Venous Thrombosis / pathology
  • Venous Thrombosis / physiopathology
  • Wound Healing


  • Anticoagulants
  • Cytokines
  • Intercellular Signaling Peptides and Proteins
  • Matrix Metalloproteinases