Venous and cerebrospinal fluid flow in multiple sclerosis: a case-control study

Ann Neurol. 2010 Aug;68(2):255-9. doi: 10.1002/ana.22132.


The prevailing view on multiple sclerosis etiopathogenesis has been challenged by the suggested new entity chronic cerebrospinal venous insufficiency. To test this hypothesis, we studied 21 relapsing-remitting multiple sclerosis cases and 20 healthy controls with phase-contrast magnetic resonance imaging. In addition, in multiple sclerosis cases we performed contrast-enhanced magnetic resonance angiography. We found no differences regarding internal jugular venous outflow, aqueductal cerebrospinal fluid flow, or the presence of internal jugular blood reflux. Three of 21 cases had internal jugular vein stenoses. In conclusion, we found no evidence confirming the suggested vascular multiple sclerosis hypothesis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Cerebral Veins / pathology
  • Cerebral Veins / physiopathology
  • Cerebrospinal Fluid / physiology*
  • Female
  • Humans
  • Hyperemia / complications
  • Hyperemia / pathology
  • Hyperemia / physiopathology*
  • Magnetic Resonance Angiography / methods
  • Male
  • Middle Aged
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / pathology
  • Multiple Sclerosis / physiopathology*
  • Young Adult