Electron Microscopic Evidence for the Association of M2 Protein With the Influenza Virion

Arch Virol. 1991;118(3-4):199-207. doi: 10.1007/BF01314030.


Immunogold electron microscopy revealed that site-specific antibodies elicited by a synthetic peptide representing the N-terminal sequence (residues 2-10) of influenza virus M2 protein were capable of binding to the surface of virions. Antibody binding was observed with two human influenza virus strains but not with an avian virus strain which has amino acid substitutions in the appropriate sequence of M2. These results provide direct evidence for the presence of M2 in the influenza virion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Influenza A virus / metabolism
  • Influenza A virus / ultrastructure
  • Influenza B virus / metabolism
  • Influenza B virus / ultrastructure
  • Influenzavirus C / metabolism
  • Influenzavirus C / ultrastructure
  • Microscopy, Immunoelectron
  • Molecular Sequence Data
  • Orthomyxoviridae / immunology
  • Orthomyxoviridae / metabolism*
  • Orthomyxoviridae / ultrastructure
  • Peptides / chemical synthesis
  • Peptides / immunology
  • Viral Matrix Proteins / metabolism*
  • Viral Matrix Proteins / ultrastructure
  • Virion / metabolism*
  • Virion / ultrastructure


  • M-protein, influenza virus
  • M2 protein, Influenza A virus
  • Peptides
  • Viral Matrix Proteins