Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents

Chem Biol Interact. 2010 Dec 5;188(3):643-50. doi: 10.1016/j.cbi.2010.07.026. Epub 2010 Aug 7.


Diabetes mellitus is associated with dyslipidemia, which is a significant risk factor for cardiovascular complications. The present study was carried out to evaluate the effects of tetrahydrocurcumin (THC) and chlorogenic acid (CGA) alone and in combination on alterations in lipids, lipoproteins and enzymes involved in lipid metabolism in streptozotocin (STZ)-nicotinamide (NA)-induced type 2 diabetic rats. A significant (p<0.05) increase in the concentrations of plasma and tissue (liver and kidney) lipids (cholesterol, triglycerides (TGs), free fatty acids (FFAs) and phospholipids (PLs)) and low density and very low-density lipoproteins (LDL and VLDL), and a decrease in the concentration of high-density lipoproteins (HDL) were noticed in STZ administered diabetic rats. In addition, the activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase increased significantly (p<0.05) in the liver and kidney whereas the activities of lipoprotein lipase (LPL) and lecithin cholesterol acyl transferase (LCAT) were decreased significantly (p<0.05) in the plasma of diabetic rats. Combined administration of CGA (5mg/kg b.w.) and THC (80mg/kg b.w.) for 45 days remarkably reduced the STZ-induced changes in lipids, lipoproteins and lipid metabolising enzymes when compared to the effects of CGA or THC alone in diabetic rats. These results indicate that combination of THC and CGA can potentially ameliorate lipid abnormalities in experimental type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chlorogenic Acid / administration & dosage
  • Chlorogenic Acid / pharmacology*
  • Curcumin / administration & dosage
  • Curcumin / analogs & derivatives*
  • Curcumin / pharmacology
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / chemically induced*
  • Diabetes Mellitus, Experimental / metabolism*
  • Diabetes Mellitus, Experimental / pathology
  • Drug Combinations
  • Hydroxymethylglutaryl CoA Reductases / metabolism
  • Hypolipidemic Agents / administration & dosage
  • Hypolipidemic Agents / pharmacology*
  • Lipoprotein Lipase / metabolism
  • Lipoproteins / blood
  • Liver / drug effects
  • Liver / pathology
  • Male
  • Niacinamide / pharmacology*
  • Phosphatidylcholine-Sterol O-Acyltransferase / metabolism
  • Rats
  • Rats, Wistar


  • Drug Combinations
  • Hypolipidemic Agents
  • Lipoproteins
  • tetrahydrocurcumin
  • Niacinamide
  • Chlorogenic Acid
  • Hydroxymethylglutaryl CoA Reductases
  • Phosphatidylcholine-Sterol O-Acyltransferase
  • Lipoprotein Lipase
  • Curcumin