Abstract
Malarial infections do not readily evoke an effective protective immunity against re-infection. Possible reasons for this include the ability of the parasites to interfere with the host's immune response and to evade the response in an immune host, by, for example, exploiting antigenic polymorphism or variation. Antigenic polymorphism undoubtedly exists in malaria parasite populations but does this polymorphism actually contribute to immune evasion by the parasite? Here, Kamini Mendis and colleagues examine the evidence for this and its implications for future malaria vaccines.
MeSH terms
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Animals
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Antigenic Variation / genetics*
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Antigens, Protozoan / genetics
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Antigens, Protozoan / immunology*
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Antigens, Surface / genetics
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Antigens, Surface / immunology
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Host-Parasite Interactions
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Humans
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Malaria / immunology*
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Plasmodium falciparum / genetics
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Plasmodium falciparum / immunology*
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Plasmodium falciparum / physiology
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Plasmodium vivax / genetics
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Plasmodium vivax / immunology*
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Plasmodium vivax / physiology
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Polymorphism, Genetic
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Protozoan Proteins / genetics
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Protozoan Proteins / immunology*
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Protozoan Vaccines
Substances
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Antigens, Protozoan
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Antigens, Surface
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Protozoan Proteins
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Protozoan Vaccines