Multi-projection fluorescence optical tomography using a handheld-probe-based optical imager: phantom studies

Appl Opt. 2010 Aug 10;49(23):4343-54. doi: 10.1364/AO.49.004343.


A handheld-probe-based optical imager has recently been developed toward three-dimensional tomography. In this study, the improvement of target depth recovery was demonstrated using a multi-projection technique on large slab phantoms using 0.45 cc fluorescing target(s) (with 1:0 contrast ratio) of 1.5 to 2.5 cm deep. Tomographic results using single- and multi- (here dual) projection measurements (with and without a priori information of target location) were compared. In all experimental cases, the use of multi-projection measurements along with a priori information recovered target depth and location closer to their true values, demonstrating its applicability for clinical translation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Breast / pathology
  • Breast Diseases / diagnosis*
  • Female
  • Fluorescence
  • Humans
  • Imaging, Three-Dimensional
  • Optical Phenomena
  • Phantoms, Imaging*
  • Tomography, Optical / instrumentation*
  • Tomography, Optical / methods*