Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1

Cell Mol Neurobiol. 2011 Jan;31(1):27-35. doi: 10.1007/s10571-010-9549-1. Epub 2010 Aug 10.


To identify the putative interacting partners for Kiaa0319-like protein. KIAA0319-like, located near the dyslexia susceptibility locus, DYX8 in chromosome 1p34.3, has been suggested as a positional candidate for developmental dyslexia due to its homology with another gene, KIAA0319 which has been strongly established as a candidate gene for developmental dyslexia. Previous research has shown that a single marker, rs7523017 (P = 0.042) has been associated with developmental dyslexia by a Canadian group. There is little functional information about this gene and protein. In this article, we put forward further evidence that support Kiaa0319-like is a candidate for this disorder. A yeast-2-hybrid screen and co-immunopreciptiation assays were performed to find protein interacting partners of KIAA0319L. A human cortex immunohistochemistry assay was performed to show the colocalization of Kiaa0319-like and its specific interacting partner in cells. Nogo Receptor 1 (NgR1), an axon guidance receptor, was identified to have physical interactions with Kiaa0319-like protein. These two proteins interact predominantly in the cytoplasmic granules of cortical neurons in the human brain cortex. Based on this data, it can be concluded that Kiaa0319-like protein interacts with Nogo Receptor 1, supporting the idea that Kiaa0319-like protein participates in axon guidance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Axons / metabolism*
  • Axons / physiology*
  • Biopsy
  • Cells, Cultured
  • Cerebral Cortex / metabolism
  • Cerebral Cortex / pathology
  • Cytoplasmic Granules / metabolism
  • Cytoplasmic Granules / pathology
  • Dyslexia* / genetics
  • Dyslexia* / metabolism
  • Dyslexia* / pathology
  • GPI-Linked Proteins / metabolism
  • Humans
  • Immunohistochemistry
  • Immunoprecipitation
  • Models, Biological
  • Myelin Proteins / metabolism*
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Nogo Receptor 1
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Protein Binding
  • Receptors, Cell Surface / metabolism*


  • GPI-Linked Proteins
  • KIAA0319L protein, human
  • Myelin Proteins
  • Nerve Tissue Proteins
  • Nogo Receptor 1
  • Nuclear Proteins
  • RTN4R protein, human
  • Receptors, Cell Surface