Gastroesophageal Reflux Disease: From Heartburn to Cancer

World J Gastroenterol. 2010 Aug 14;16(30):3743-4. doi: 10.3748/wjg.v16.i30.3743.

Abstract

About 10%-15% of patients with gastroesophageal reflux disease develop Barrett's esophagus. This is considered a premalignant condition because it can progress from metaplasia to high-grade dysplasia, and eventually to adenocarcinoma. Recently, major advances have been made in the endoscopic treatment of Barrett's esophagus, therefore limiting the role of surgery in the treatment of this disease.

Publication types

  • Editorial
  • Introductory Journal Article

MeSH terms

  • Adenocarcinoma / etiology*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy
  • Barrett Esophagus / etiology*
  • Barrett Esophagus / pathology
  • Barrett Esophagus / therapy
  • Disease Progression
  • Esophageal Neoplasms / etiology*
  • Esophageal Neoplasms / pathology
  • Esophageal Neoplasms / therapy
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / therapy
  • Heartburn / etiology*
  • Heartburn / therapy
  • Humans
  • Precancerous Conditions / etiology*
  • Precancerous Conditions / pathology
  • Precancerous Conditions / therapy
  • Treatment Outcome