Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1

Masataka Narukawa; Kanako Koizumi; Yusaku Iwasaki; Kikue Kubota; Tatsuo Watanabe

doi:10.1271/bbb.100133

Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1

Biosci Biotechnol Biochem. 2010;74(8):1694-6. doi: 10.1271/bbb.100133. Epub 2010 Aug 7.

Authors

Masataka Narukawa¹, Kanako Koizumi, Yusaku Iwasaki, Kikue Kubota, Tatsuo Watanabe

Affiliation

¹ Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka, Japan.

PMID: 20699565
DOI: 10.1271/bbb.100133

Abstract

We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1'-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alpinia / chemistry*
Benzyl Alcohols / pharmacology*
Calcium Channels / metabolism*
HEK293 Cells
Humans
Nerve Tissue Proteins / agonists
Nerve Tissue Proteins / metabolism*
Odorants*
TRPA1 Cation Channel
TRPV Cation Channels / metabolism
Transient Receptor Potential Channels / agonists
Transient Receptor Potential Channels / metabolism*

Substances

Benzyl Alcohols
Calcium Channels
Nerve Tissue Proteins
TRPA1 Cation Channel
TRPA1 protein, human
TRPV Cation Channels
TRPV1 protein, human
Transient Receptor Potential Channels
1'-acetoxychavicol acetate