Prevalence and risk factors for esophageal squamous cell cancer and precursor lesions in Anyang, China: a population-based endoscopic survey

Br J Cancer. 2010 Sep 28;103(7):1085-8. doi: 10.1038/sj.bjc.6605843. Epub 2010 Aug 10.


Background: The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions of China remains unclear.

Methods: Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 of Anyang, China.

Results: In this study, 2.57, 0.20 and 0.16% of the participants had mild, moderate and severe squamous dysplasia, respectively; 0.19 and 0.08% showed squamous carcinoma in situ and invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio=0.72, 95% confidence interval: 0.54-0.96) was negatively associated with ESCC and its precursors, whereas tobacco and alcohol use were not significantly associated with ESCC.

Conclusions: Water source and other factors in this region need further evaluation by longitudinal studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alcohol Drinking / adverse effects
  • Carcinoma, Squamous Cell / epidemiology*
  • China / epidemiology
  • Esophageal Neoplasms / epidemiology*
  • Esophagoscopy
  • Esophagus / pathology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Precancerous Conditions / epidemiology*
  • Prevalence
  • Risk Factors
  • Smoking / adverse effects
  • Water Supply