New functions of aminoacyl-tRNA synthetases beyond translation

Nat Rev Mol Cell Biol. 2010 Sep;11(9):668-74. doi: 10.1038/nrm2956. Epub 2010 Aug 11.


Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively incorporated domains and motifs that have no essential connection to aminoacylation reactions. Their accretive addition to virtually all aaRSs correlates with the progressive evolution and complexity of eukaryotes. Based on recent experimental findings focused on a few of these additions and analysis of the aaRS proteome, we propose that they are markers for aaRS-associated functions beyond translation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acyl-tRNA Synthetases / genetics
  • Amino Acyl-tRNA Synthetases / metabolism*
  • Animals
  • Eukaryota / enzymology
  • Eukaryota / genetics
  • Evolution, Molecular
  • Humans
  • Protein Biosynthesis*


  • Amino Acyl-tRNA Synthetases