Interrelationships between hepatic fat and insulin resistance in non-alcoholic fatty liver disease

Curr Diabetes Rev. 2010 Sep;6(5):341-7. doi: 10.2174/157339910793360879.


Non-alcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, and its prevalence is rising in parallel with worldwide increases in obesity and type 2 diabetes. However, the nature of this relationship remains debatable. In particular, it is unclear whether insulin resistance causes NAFLD or hepatic steatosis per se reduces insulin sensitivity. This review will examine data from recent studies on the link between insulin resistance and NAFLD, focusing on studies that have attempted to dissociate fatty liver and hepatic insulin resistance.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Adipose Tissue / physiology*
  • Animals
  • Fatty Liver / complications
  • Fatty Liver / etiology
  • Fatty Liver / metabolism
  • Humans
  • Insulin Resistance / physiology*
  • Lipid Metabolism / physiology*
  • Liver / metabolism*
  • Mitochondrial Diseases / complications
  • Mitochondrial Diseases / metabolism
  • Models, Biological
  • Non-alcoholic Fatty Liver Disease