Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model

Arthritis Res Ther. 2010;12(4):130. doi: 10.1186/ar3082. Epub 2010 Jul 28.


Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and that this is related to alterations in locomotor function. Furthermore, a high-fat diet leads to pain sensitization and depression/anxiety-like behavior unrelated to structural OA changes in the knee. Their findings demonstrate that the majority of features of the human 'OA syndrome' can be reproduced in a small animal model.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Animals
  • Dietary Fats / pharmacology*
  • Disease Models, Animal*
  • Mice
  • Mice, Inbred C57BL*
  • Motor Activity
  • Obesity, Abdominal / epidemiology*
  • Osteoarthritis / epidemiology*
  • Osteoarthritis / physiopathology
  • Risk Factors


  • Dietary Fats