Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy

J Neuroimmunol. 2010 Sep 14;226(1-2):177-80. doi: 10.1016/j.jneuroim.2010.07.005. Epub 2010 Aug 11.


Anti-SOX1 antibodies have been described to be positive in patients with paraneoplastic Lambert-Eaton myasthenic syndrome and, in a lower amount, in patients with anti-Hu positive paraneoplastic neurological syndromes, and with SCLC alone, respectively. We found 5/32 patients with paraneoplastic neuropathy and, surprisingly, 4/22 patients with neuropathy of unknown origin positive for anti-SOX1 antibodies, whereas no patient with inflammatory neuropathy and no healthy controls showed any reactivity (p=0.007). All patients with neuropathy of unknown origin where followed up for four years without diagnosis of a tumour so far. Anti-SOX1 antibodies are associated with paraneoplastic neuropathies and may define another group of non-paraneoplastic, immune-mediated neuropathies.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Animals
  • Autoantibodies / metabolism*
  • Cell Line, Transformed
  • ELAV Proteins / immunology
  • Female
  • Humans
  • Lambert-Eaton Myasthenic Syndrome / immunology*
  • Lambert-Eaton Myasthenic Syndrome / metabolism
  • Male
  • Mice
  • Middle Aged
  • Paraneoplastic Polyneuropathy / immunology*
  • Paraneoplastic Polyneuropathy / metabolism
  • Paraneoplastic Syndromes, Nervous System / classification
  • Paraneoplastic Syndromes, Nervous System / immunology
  • Paraneoplastic Syndromes, Nervous System / metabolism
  • SOXB1 Transcription Factors / immunology*
  • Transfection / methods


  • Autoantibodies
  • ELAV Proteins
  • SOXB1 Transcription Factors