The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma

Leukemia. 2010 Oct;24(10):1781-4. doi: 10.1038/leu.2010.154. Epub 2010 Aug 12.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Combined Chemotherapy Protocols
  • Apoptosis / drug effects
  • Blotting, Western
  • Boronic Acids / pharmacology
  • Bortezomib
  • Cell Proliferation / drug effects
  • Female
  • Forkhead Transcription Factors / physiology
  • Humans
  • Imidazoles / pharmacology*
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors*
  • Intracellular Signaling Peptides and Proteins / genetics
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Lymphoma, Follicular / drug therapy*
  • Lymphoma, Follicular / metabolism
  • Lymphoma, Follicular / pathology
  • Mice
  • Mice, Nude
  • Phosphatidylinositol 3-Kinases / genetics
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphoinositide-3 Kinase Inhibitors*
  • Protein Kinase Inhibitors / pharmacology*
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • Pyrazines / pharmacology
  • Quinolines / pharmacology*
  • RNA, Messenger / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • TOR Serine-Threonine Kinases
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Boronic Acids
  • Forkhead Transcription Factors
  • Imidazoles
  • Intracellular Signaling Peptides and Proteins
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Kinase Inhibitors
  • Pyrazines
  • Quinolines
  • RNA, Messenger
  • Whn protein
  • Bortezomib
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • mTOR protein, mouse
  • Protein-Serine-Threonine Kinases
  • dactolisib